Xue JM, et al. - Researchers assessed the role of survivin in the development and maintenance of T helper 2 (Th2) polarization. CD4⁺ T cells have been isolated from blood samples from subjects with allergic asthma (AS) and HS control (HS). Mice carrying CD4⁺ T cells with survivin knockout (KO mice) were used to test survivin's role in biased Th2 responses development. Findings revealed that KO mice were unable to induce airway allergy. Peripheral CD4⁺ T cells expressed survivin, which in the AS group was higher than in the HS group. It was noted that Fas expression was lower in CD4⁺ T cells of the AS group than that in the HS group. According to results, survivin facilitates the development of biased Th2 polarization by promoting interleukin 4 expression and impairing CD4⁺ T cells activation-induced cell death machinery. There is translational potential in the treatment of allergic diseases to modulate survivin expression in CD4⁺ T cells.