Xanthopoulos EP, et al. - Researchers assessed overall and cause-specific survival among node-positive, American Joint Committee on Cancer version 6-staged women with squamous cell vulvar carcinoma treated with and without radiation following surgery found using the Surveillance, Epidemiology, and End Results (SEER) database. They wished to determine the benefit of adjuvant radiation therapy in patients with vulvar cancer and 1 positive lymph node. Adjuvant radiation was related to improved median overall survival across all node-positive patients, as observed during a median follow-up of 36 months. Persistence of this survival benefit was seen in women with just one and 2+ positive lymph nodes. On multivariable Cox regression, adjuvant radiation, age, tumor diameter, number of positive nodes, race, and N-stage were found to be related to survival.