Ruiz ES, et al. - Experts evaluated outcomes of individuals with primary cutaneous squamous cell carcinoma (CSCC, the second most prevalent malignant neoplasm in the United States, with an estimated one million incidents diagnosed yearly) who were treated with salvage limited-field irradiation for microscopic residual disease following surgery. With surgery alone, most individuals have an outstanding prognosis, however, a small subset has poor outcomes. Results are considerably influenced by margin status after surgery. Entire circumferential peripheral and deep margin evaluation, which includes en face sectioning to permit for approximately 100% histologic margin evaluation, is correlated with lower recurrence rates in comparison with standard evaluation, in which nearly 1% of the margin is assessed (A. Waldman, MD, written communication, January 2019). National Comprehensive Cancer Network guidelines for CSCC incorporate salvage radiation therapy as an alternative for positive histologic margins following surgical excision. Nonetheless, limited data assessing outcomes following salvage radiation therapy were noted.