van Veen DE, et al. - Authors conducted a retrospective, single-center, cohort study gauged a sufentanil sublingual tablet system (Zalviso) to optimize postoperative pain treatment. More nausea was experienced by patients treated with Zalviso compared to other groups on day 0 and day 1. A higher percentage of mobilization on the day of surgery was seen in patients treated with Dexa + Oxy compared to Oxy and Zalviso. In conclusion, an improvement in postoperative pain management in patients undergoing total knee arthroplasty was not seen with Zalviso and it increased nausea.