Palanca A, et al. - Using data from the National Observatory of Atherosclerosis in Nephrology cohort, researchers assessed the prognostic significance of subclinical atherosclerosis in ascertaining the incidence of first cardiovascular events (CVEs) in patients with diabetes and chronic kidney disease (CKD) vs patients with CKD but not diabetes. Data were analyzed for patients with CKD with and without diabetes, free from pre-existing cardiovascular disease. Participants were followed-up for a mean duration of 48 months, during which time 203 CVEs were documented. Among participants without diabetes and those with diabetes, 107 CVEs (19.58 per 1,000 person-years) and 96 CVEs (44.44 per 1000 person-years) were reported. In diabetic individuals with CKD, future CVEs were most strongly predicted by the burden of subclinical atherosclerosis. In this population, an improved CVE prediction could be achieved via early disclosure of subclinical atherosclerotic burden by multi-territorial vascular ultrasound.