Yamanaka H, et al. - This study entailed the comparison between 3 preventive strategies for reducing gout flares during the initial introduction of urate-lowering therapy in patients with gout: stepwise dose increase of febuxostat, fixed-dose febuxostat + colchicine, and fixed-dose febuxostat. Findings demonstrated a greater efficacy of stepwise dose increase of febuxostat and low-dose colchicine prophylaxis in attenuating gout flares in comparison with fixed-dose febuxostat alone. It was observed that stepwise dose increase of febuxostat may be an effective alternative to low-dose colchicine prophylaxis during the introduction of urate-lowering therapy.