An K, et al. - Since the combination of statins and clopidogrel in patients with coronary artery disease (CAD) is frequently administered, researchers ascertained if statins reduce mortality in patients undergoing clopidogrel treatment without affecting platelet activation and aggregation. A total of 28 studies were included in this analysis, representing 25,267 participants. According to findings, statins reduce mortality with either cytochrome P450 isoenzyme 3A4 (CYP3A4) metabolized statin or non-CYP3A4 metabolized statin in patients undergoing clopidogrel treatment without affecting platelet activation and aggregation. However, the level of triglycerides is reduced compared with non-CYP3A4 metabolized statin when administered with clopidogrel and CYP3A4. It is still unknown how clopidogrel affects lipid parameters and clinical outcomes in people receiving statin.