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Statin use reduced hepatocellular carcinoma risk in patients with NAFLD

Clinical Gastroenterology and Hepatology Feb 15, 2022

Strong evidence for decreased risk of hepatocellular carcinoma (HCC) in relation to statin initiation in non-alcoholic fatty liver disease (NAFLD) patients was generated in this study.

Observations indicate that statin can be employed as a protective medication for NAFLD patients to attenuate the risk of HCC.

  • Recent evidence indicates potential clinical advantages of statin in cancer chemoprevention and treatment.

  • The Optum de-identified Clinformatics database was used in this study including 272,431 adults with NAFLD diagnosis.

  • In the inverse probability of treatment weighting model, a 53% less risk of developing HCC was present in statin initiators vs nonusers (hazard ratio,HR: 0.47).

  • In the sub-cohort with FIB-4 data available, statin initiation was found to be related to a 56% hazard reduction of developing HCC in NAFLD post-adjusting for FIB-4 score (HR: 0.44).

  • For both lipophilic statin and hydrophilic statin, the relationship between statin initiation and lower risk of HCC development was evident, with HRs 0.49 and 0.40, respectively.

  • A greater hazards reduction was obvious as the dose and duration of statin use increased.

  • A 70% decrease in hazards of developing HCC (HR: 0.30) was noted in relation to more than 600 cumulative defined daily doses of statin use, among NAFLD patients.


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