Mortensen MB, et al. - In a population-based, contemporary cohort study that included 45,750 adults (40-75 years of age), experts contrasted the sensitivity, specificity, and predicted number needed to treat (NNT₁₀) to prevent one atherosclerotic cardiovascular disease (ASCVD) event in 10 years according to statin criteria from 5 guidelines. During follow-up, a total of 4,156 ASCVD events occurred. With similar NNT₁₀ to prevent a single event, the Canadian Cardiovascular Society (CCS), American College of Cardiology/American Heart Association (ACC/AHA), and National Institute for Health and Care Excellence (NICE) guidelines accurately designated statin therapy to many more of the individuals who later develop ASCVD vs the US Preventive Services Task Force and European Society of Cardiology/European Atherosclerosis Society guidelines. Overall, the researchers suggested that the CCS, ACC/AHA, or NICE guidelines may be preferable for primary prevention.