Lee YT, Wang JJ, Luu M, et al. - Researchers sought to determine state-level racial/ethnic differences in hepatocellular carcinoma (HCC) incidence, state-level temporal alterations in HCC incidence, as well as the ecological correlation between HCC incidence and obesity/physical activity levels in the USA. They obtained data from the Centers for Disease Control and Prevention’s National Program of Cancer Registries and the National Cancer Institute’s Surveillance, Epidemiology and End Results, to compute trends in HCC incidence between 2001 and 2017. They found that HCC incidence rate ratios ranged between 6.3 and 0.9 in Blacks, 6.1 and 1.7 in Asians/Pacific Islanders, 3.8 and 0.9 in Hispanics, and 6.0 and 0.9 in American Indians/Alaska Natives (vs Whites as reference). Findings demonstrated the existence of a wide state-level variation in racial/ethnic disparity of HCC incidence. Across states, disparate incidence trends were observed, with HCC incidence continuing to rise in over half of the states. Moderate correlations of both regional obesity and lack of physical activity with HCC incidence trends were found, indicating that increasing HCC incidence may be curbed via interventions targeting these factors.