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Spectrum of retinal abnormalities in renal transplant patients using chronic low-dose steroids

Graefe's Archive for Clinical and Experimental Ophthalmology Nov 24, 2017

van Dijk EHC, et al. - This study was designed in order to inspect the ophthalmological characteristics of asymptomatic patients, with a renal transplant on chronic low-dose steroids for at least the last 2 years prior to the examination. In maximum patients of the study cohort, retinal abnormalities appeared to be common. These retinal changes could be related to the renal disease and/or the effect of chronic steroid use on the choroid and retina.

Methods

  • The scheme of this research was a cross-sectional study.
  • Herein, all patients underwent an extensive ophthalmological examination.

Results

  • Among the 37 included patients [25 male, 12 female; 59 ± 11 years (range, 38-77 years)] ophthalmological phenotyping disclosed abnormalities in 22 patients (59%).
  • In 10 patients (27%), findings characteristic for (subclinical) central serous chorioretinopathy were detected, including 2 patients with serous subretinal fluid in the macula.
  • The presence of an epiretinal membrane of the macula was noted in 6 patients (16%).
  • A substantial rise was discovered in the mean subfoveal choroidal thickness, in patients with ophthalmological abnormalities, when compared to patients without abnormalities.

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