Esposito P, et al. - A soluble form of extracellular Toll-like receptor 4 (sTLR4) has been recently characterized, which showed the ability to attenuate TLR4 signalling. Herein, the sTLR4 profile in regular hemodialysis patients (HD) patients were assessed. Findings showed correlation of sTLR4 with inflammatory and nutritional parameters. This implies sTLR4 to be a new potential player in modulating subclinical inflammation in HD patients.