Leaños-Miranda A, et al. - In this study including 1,002 women with preeclampsia, researchers examined the association of sEng (soluble endoglin) with preeclampsia severity, clinical, and laboratory parameters, and the occurrence of adverse consequences. ELISA was used to measure serum sEng levels. A positive correlation of sEng with blood pressure, proteinuria, and levels of creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, was found. Its inverse link with gestational age, infant’s birth weight, and platelet counts was also evident. Patients with sEng values in the highest quartile vs those in the lowest quartile had a higher risk of combined and specific adverse outcomes (pulmonary edema, acute renal failure, placental abruption, hepatic hematoma or rupture, maternal death, cerebral hemorrhage, thrombocytopenia, elevated liver enzymes, preterm delivery, small for gestational age infant, and requirement for endotracheal intubation, positive inotropic drug support, and hemodialysis). Furthermore, the likelihood of delivering early was more in those in the highest quartile vs in the lowest quartile. Overall, circulating sEng levels appeared to be a suitable marker to evaluate the severity of preeclampsia.