Schrijvers R, et al. - The negative predictive value (NPV) of skin testing for iodinated contrast medium (ICM) hypersensitivity, was assessed herein. Findings indicated that particularly in patients with an immediate hypersensitivity reaction and/or skin test-proven ICM drug allergy, skin testing for potential ICM hypersensitivity can identify safe alternative(s) for ICM re-exposure. Notably, re-exposure induced infrequent reactions, which were mostly milder, and occurred in some patients despite premedication.