Gholami S, et al. - Researchers sought to delineate the prognostic factors for recurrence and disease-specific death (DSD) in resected primary solitary fibrous tumors (SFTs). They recognized marked association of recurrence with DSD and events occurred as late as 16 years after initial presentation, including in patients with initially considered benign tumors. The greatest risk was observed for patients with large (≥ 8 cm) tumors in the chest or abdominal/retroperitoneal cavity.

Methods

• Researchers identified resected primary SFTs from 1982 to 2015 from a prospective, single institutional database.
• They assessed risk factors for local (LR) and distant recurrence (DR), and DSD using competing risk analysis.

Results

• This study included 219 patients; median follow-up of 6.1 (0.1–22) years was performed.
• Findings revealed five- and 10-year cumulative DSD of 9 and 11%, respectively.
• DSD seemed to have significant correlation with size greater than the median 8 cm, gender, location, and complete gross resection(p < 0.05).
• LR had five- and 10-year cumulative risk (CR) of 4 and 7%.
• However, 5- and 10-year CR of DR was 13 and 16%, respectively.
• LR seemed to have correlation with location (p = 0.02) and tumor size (p = 0.02); DR seemed to have correlation with size (p < 0.01).
• Histopathologic classification was not predictive of long-term behavior with both malignant and benign tumors demonstrating capacity for DR and associated death.
• The greatest risk of DR was observed for tumors in the thoracic cavity and abdomen/retroperitoneum (16 and 27% 10-year CR).
• Multivariate analysis suggested that size ≥ 8 cm (hazard ratio 2.89, p = 0.05) and tumor location in chest or abdominal/retroperitoneal cavity (hazard ratio 2.68, p = 0.01) markedly impacted DSD.