Hata T, et al. - Researchers here developed a nested real-time quantitative PCR method for telomere fusion detection in pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms (IPMNs), and IPMN cyst fluids. They recognized a higher telomerase activity levels in cyst fluids with fusions than in those without. Multivariate analysis revealed cyst fluid telomere fusion status as an independent predictor of high-grade dysplasia (HGD)/invasive cancer. They detected telomere fusions in later stages of IPMN progression. These could serve as a marker for predicting the presence of HGD and/or invasive cancer.