Syue YJ, Li CJ, Chen WL, et al. - In this retrospective study of 406 children (< 18 years) who showed up in the emergency department with an initial episode of acute angioedema and who had subsequent follow-up visits in the out-patient department from January 2008 to December 2014, experts investigated the factors prognosticating the severity and outcomes of the first attack of acute angioedema in children. The prognosticators of severe angioedema were discovered to be the co-occurrence of pyrexia or urticaria, etiologies associated with medications or infections, the presence of respiratory symptoms, and a history of allergies. Moreover, importantly, for individuals who did not need hospital admission, short-term pediatric observation unit observation and prompt treatment could be an advantage.