Meites E, Stone L, Amiling R, et al. - Human papillomavirus (HPV) presumably acquired during vaginal delivery rarely results in a serious disease, named juvenile onset recurrent respiratory papillomatosis (JORRP). Since 2006, HPV vaccination of females through age 26 years has been recommended in the United States, which can prevent HPV transmission. In this study, trends in JORRP cases, before and after HPV vaccine introduction in the United States, were assessed. From 26 pediatric otolaryngology centers in 23 US states, they obtained data of 576 US JORRP case-patients born in 2004-2013. Findings revealed a significant decline in the numbers of JORRP case-patients and incidences over the decade. Use of national denominator data likely generate underestimates concerning incidence measures; use of state-level denominator data could provide overestimates. Most likely, these reductions are because of HPV vaccination. Increase in vaccination uptake could result in elimination of this HPV-related disease.