Kuuliala K, et al. - In acute pancreatitis (AP) complicated by organ dysfunction (OD), intracellular signaling in blood leukocytes shows multiple aberrations. In this study, researchers investigated if there existed any possible association of the aberrations with AP severity, and their occurrence in sepsis complicated by OD. Findings revealed that signaling aberrations in sepsis with OD mimicked those described previously in AP with OD. Further exploration is warranted, including patients presenting without OD but developing it during follow-up, for the possibility that aberrations in signal transducers and activators of transcription (STAT)1 and STAT3 pathways provide novel markers predicting evolution of OD.