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Short-term effects of dexamethasone vs betamethasone on ultrasonic measures of fetal well-being: Cohort from a blinded, randomized trial

Fetal Diagnosis and Therapy Aug 03, 2021

Henry A, Mahajan A, Crowther CA, et al. - Researchers conducted a substudy of blinded randomized trial of dexamethasone vs betamethasone (given < 34 weeks) for anticipated preterm birth, with the aim to examine short-term ultrasound and cardiotocograph (CTG) impact of (a) dexamethasone vs betamethasone (b) pooled corticosteroid effect. Outcomes revealed no substantial post corticosteroid effects for most ultrasound/CTG measures in fetuses with heightened preterm birth risk but predominantly normal pre-corticosteroid measures. In view of this finding, they suggest avoiding overreliance on individual measures for delivery decisions post corticosteroid in clinical setting; equally, true pathology and not corticosteroid effect are indicated by multiple/marked ultrasound changes.

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