Moonen L, et al. - As acute kidney injury (AKI) is an important risk factor for the development of chronic kidney disease (CKD), researchers investigated if temporary suppression of inflammation immediately after AKI is a good first-line therapeutic strategy towards a better long-term outcome. For this purpose, they made male C57Bl/6 J mice (Charles River, 10–12 weeks of age) to undergo warm (36 °C body temperature) unilateral ischemia-reperfusion of the kidney for 21 min, after which they initiated treatment with intraperitoneal injection of the corticosteroid dexamethasone (10 mg/kg) for 3 weeks. Observations revealed only transient attenuation of ischemia-induced fibrosis with a short-term anti-inflammatory therapy with dexamethasone. This justifies prolonged or persistent anti-inflammatory treatment for achieving a long-term benefit.