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Short‐term variability of the QT interval can be used for the prediction of imminent ventricular arrhythmias in patients with primary prophylactic implantable cardioverter defibrillators

Journal of the American Heart Association Dec 05, 2020

Smoczyńska A, Loen V, Sprenkeler DJ, et al. - Researchers investigated if imminent ventricular arrhythmias in patients can be predicted by short‐term variability of the QT interval (STVQT). As part of the EU‐CERT‐ICD (European Comparative Effectiveness Research to Assess the Use of Primary Prophylactic Implantable Cardioverter Defibrillators) study, 24‐hour ECG Holter recordings were collected in 2,331 patients with primary prophylactic implantable cardioverter defibrillators. Prior to nonsustained ventricular arrhythmia, nonsustained ventricular tachycardia, and sustained ventricular tachycardia, an increase in STVQT was evident from 0.80 ± 0.43 ms to 1.18 ± 0.78 ms, from 0.90 ± 0.49 ms to 1.14 ± 0.70 ms, and from 1.05 ± 0.22 ms to 2.33 ± 1.25 ms. In sustained ventricular tachycardia, this increase in STVQT was found to be significantly higher vs nonsustained ventricular arrhythmia. Overall, findings showed a rise in STVQT prior to imminent ventricular arrhythmias in patients, and there was a link between the extent of the increase and the severity of the ventricular arrhythmia.

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