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Shifts in the skin microbiota after UVB treatment in adult atopic dermatitis

Dermatology Apr 27, 2021

Lossius AH, Sundnes O, Ingham AC, et al. - Since the pathophysiology in atopic dermatitis (AD) is not fully understood, but immune dysfunction, skin barrier defects, and alterations of the skin microbiota are thought to play important roles, researchers sought to map the temporal shifts in the microbiota of the skin, nose, and throat in adult AD patients after narrow-band ultraviolet B (nb-UVB) treatment. Before and after 3 treatments of nb-UVB, as well as 6–8 weeks of full-body therapy, skin swabs were taken from lesional AD skin (n = 16). Samples were also obtained from non-lesional skin (NLS) and from the nose and throat. After 6–8 weeks of therapy, the microbiota of lesional AD skin shifted toward greater variety, while the microbiota of the NLS and the nose/throat stayed unchanged. There were no significant changes in the microbiota after only 3 treatments with nb-UVB.

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