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Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men

Journal of Diabetes Investigation May 08, 2020

Kaga H, Tamura Y, Takeno K, et al. - Given a higher risk for type 2 diabetes in individuals with a monophasic glucose response curve (GRC) during a 75‐g oral glucose tolerance test vs those with a biphasic GRC, researchers sought to address the association between GRC type and insulin clearance. Forty-nine healthy non‐obese Japanese men were divided into the monophasic or biphasic group based on the shape of their GRC. Compared with the biphasic group, the monophasic group exhibited more visceral fat, lower insulin clearance and lower muscle insulin sensitivity, but comparable liver and adipose tissue insulin sensitivity, and insulin secretion. In conclusion, insulin clearance and muscle insulin sensitivity are lower in healthy non‐obese men with a monophasic GRC.

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