Krueger EA, et al. - Researchers assessed nationally representative data collected in 2012–2013 (n = 34,597) to appraise disparities in past-year DSM-5 alcohol, cannabis, and tobacco use disorders across 4 sexual orientation groups (heterosexuals and 3 sexual minority subgroups, lesbian/gay-, bisexual-, and heterosexual-identified sexual minorities). They examined how stressful life events are correlated to substance use disorder differences between heterosexuals and each sexual minority subgroup, and whether stressful life events and lesbian, gay, and bisexual discrimination events mediated these substance use disorder differences. Variation in substance use disorders and stress experiences by sexual identity was noted for both men and women. They identified a greater prevalence of substance use disorders among sexual minority subgroups, this was mediated through both stressful life events and lesbian, gay, and bisexual discrimination.