Wang TY, et al. - In this observational prospective study, researchers investigated the sex-specific disparities in clinical management and in-hospital outcomes in adults undergoing transcatheter aortic valve implantation (TAVI) with newer generation transcatheter heart valves (THVs). Participants included 298 consecutive patients who had TAVI and received a newer generation THV from December 2015 to June 2018 at an academic tertiary medical center. The investigators found that, although clinical presentation and procedural management differed by sex, men and women demonstrated no significant difference in clinical outcomes. However, they noted that women were older, had lower serum creatinine, higher left ventricular ejection fraction, and lower rates of multiple comorbidities, including prior coronary artery bypass graft surgery, prior myocardial infarction, and atrial fibrillation vs men. In addition, women, compared with men, had smaller aortic annular area and perimeter, and received implantation of smaller THVs.