Karere GM, Cox LA, Bishop AC, et al. - In this cross-sectional analysis, researchers investigated 68 (60% male) Hispanic adolescents with obesity (aged 13-17 years) in order to determine gender disparities in microRNA (miRNA) expression, anthropometric measures as well as cardiometabolic risk factors among them. Per findings, differences in five miRNAs (miR-24-3p, miR-361-3p, miR-3605-5p, miR-486-5p and miR-199b-3p) were evident between men and women participants. PI3K-AKT, AMPK, insulin resistance, sphingolipid, TGF-beta, adipocyte lipolysis regulation and oxytocin signaling pathways were revealed as miRNA targets-enriched pathways. Blood pressure, skeletal muscle mass, lean body mass and percent body fat, all differed by gender. Herein, Hispanic adolescents exhibited gender disparities in miRNA expression relevant to cardiometabolic health.