Syme C, et al. - Given the existence of multiple sex differences in mechanistic pathways that increase blood pressure (BP) in overweight/obesity, researchers investigated if these differences lead to a sex-specific pattern of BP hemodynamics—males and females may vary in the relative contributions of stroke volume, total peripheral resistance (TPR), and heart rate to higher BP. The population-based sample of middle-aged adults (36–65 years) comprised 618 individuals (289 males and 329 females; 79% of males and 66% of females were overweight). Overweight/obese individuals displayed marked sex differences in BP hemodynamics: TPR was the main determinant of higher BP in males (49% vs only 35% in females) whereas it was stroke volume in females (51% vs only 35% in males). When standing or sitting at rest, these sex differences were most apparent. Normal-weight individuals showed no such differences; among these, both sexes exhibited TPR as the main determinant of higher BP.