Santas E, Palau P, Llácer P, et al. - Findings showed absence of gender‐related differences in all‐cause mortality risk after an admission for acute heart failure (HF). However, women in comparison to men exhibited a lower risk of cardiovascular and HF‐mortality at the lower extreme of left ventricular ejection fraction (LVEF). Whereas, they demonstrated a higher risk of HF death at the upper extreme.

• In this retrospective analysis, 4812 patients admitted for acute HF [46.6% were women, 53.4% were men, and 54.2% showed LVEF≥50%] were analyzed to assess gender‐related disparities in 6‐month death risk across LVEF after admission for acute HF.

• Death occurred in 13.4% (n=645), being 11.3% and 8.6% cardiovascular and HF‐related deaths, respectively.

• No independent association of LVEF was observed with mortality (hazard ratio, 1.02).

• No gender-related differences in all‐cause death were seen post-multivariable adjustment.

• However, across LVEF, there existed a significant interaction between gender and cardiovascular and HF mortality risks.