Ginsberg C, Houben AJHM, Malhotra R, et al. - Given that microvascular dysfunction resulting from a higher serum phosphate has been suggested in studies but there is a lack of links in humans with direct measures of microvascular function, researchers undertook this cross-sectional study to evaluate the link between serum phosphate and each microvascular outcome in 3,189 community-living participants. Skin capillary recruitment during postocclusive peak reactive hyperemia by capillaroscopy was considered as the primary outcome. They also assessed capillary recruitment during venous congestion, heat-induced skin hyperemic response, flicker light–induced retinal arteriolar, and venular dilation as secondary outcomes. They found an independent link of a 1 mg/dl higher serum phosphate with a 5.0% lower postocclusive capillary recruitment. They found similar outcomes for capillary recruitment with venous congestion. Independent link of a 1 mg/dl higher serum phosphate with a 0.23% lower retinal venular dilation in response to flicker light was also observed. Men but not women exhibited a lower heat-induced skin hyperemic response in relation to a higher serum phosphate. Overall, microvascular dysfunction in community-living people was evident in correlation with higher serum phosphate levels, even within the normal range.