Asada M, Oishi E, Sakata S, et al. - Researchers performed a longitudinal study examining how serum LBP (lipopolysaccharide-binding protein) levels are associated with the incidence of cardiovascular disease (CVD) in general populations. They performed 10 years follow-up of 2,568 community-dwelling Japanese individuals 40 years and older without prior CVD (2002–2012) and identified CVD development in 180 of these individuals. The analysis revealed a significantly higher risk of CVD development among individuals with higher serum LBP levels after adjusting for conventional cardiovascular risk factors. Low-grade endotoxemia via chronic systemic inflammation may contribute to the pathogenesis of CVD.