Serum lipids and suicidal risk among patients with schizophrenia spectrum disorders: systematic review and meta‐analysis
Acta Psychiatrica Scandinavica Apr 14, 2021
Sankaranarayanan A, Pratt R, Anoop A, et al. - In people with schizophrenia spectrum disorders, a systematic review was performed to ascertain the relationship between serum lipids and suicidality. Researchers conducted a systematic search of multiple databases for studies that determined the relationship between serum lipids and suicidality in adult patients with schizophrenia spectrum disorders (18‐65 years old) from database inception to September 2, 2020. National Institute of Health scales were used to conduct qualitative analysis. They calculated standard Mean Difference and 95% confidence intervals for each study and standardized relative to the study. They computed adjusted p‐value, Z‐test, and heterogeneity, as well as testing for publication bias. They included 17 studies, including a total of 3,113 participants, in the systematic review, while 11 studies were included in the meta‐analysis. In people with schizophrenia spectrum disorders, suicide attempts are correlated with low mean total cholesterol levels. People with history of suicide attempt had a mean cholesterol value 0.56 SD lower than the mean in those without suicide attempts.
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