Eskiizmir G, Ellidokuz H, Başpınar Y, et al. - Researchers undertook this prospective, cohort study to ascertain the levels of serum hypoxia-inducible factor-1, -2 and -3 (HIF-1, -2 and -3) among patients suffering from laryngeal neoplasm, as well as to inquire about their role in differential diagnosis, prediction of tumour characteristic and extension, and prognosis and survival. This analysis involved 64 patients with a laryngeal neoplasm. It was found that there was an adverse impact of high serum HIF-2 level on survival and locoregional control, and was identified to have more than 7-fold increase in hazard ratio. Overall, hypoxia-inducible factor-2 was revealed to have a role as a prognostic factor in larynx cancer, regardless of treatment modality, in this first clinical study assessing the diagnostic, predictive and prognostic roles of hypoxia-related biomolecules in laryngeal cancers.