Simunovic M, et al. - In obese children and adolescents, researchers measured serum catestatin concentrations, using an enzyme-linked immunosorbent assay, relative to presence or absence of metabolic syndrome (MS), as well as the possible links between catestatin levels and other cardiovascular risk factors. This study included 92 obese subjects (aged 10 to 18 years) with a body mass index z score > 2. Controls were 39 healthy, normal weight subjects. In this first-ever study addressing these topics, lower serum catestatin concentrations were detected among obese subjects with MS vs obese subjects without MS and controls. Findings revealed a significant negative correlation of serum catestatin concentrations with diastolic blood pressure, homeostatic model assessment of insulin resistance, and high sensitivity C-reactive protein.