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Serum calcitriol concentrations and kidney function decline, heart failure, and mortality in elderly community-living adults: The Health, Aging, and Body Composition Study

American Journal of Kidney Diseases Jun 11, 2018

Selamet U, et al. - Researchers explored the associations of calcitriol concentrations with major kidney function decline (≥ 30% decline in estimated glomerular filtration rate from baseline), incident heart failure (HF), and all-cause mortality during 10 years of follow-up in well-functioning community-living older adults aged 70 to 79 years at inception who participated in the Health, Aging, and Body Composition (Health ABC) Study. They found an independent association of lower calcitriol concentrations with kidney function decline. No significant association of calcitriol with incident HF or mortality was seen. In addition, no significant interactions were shown between calcitriol concentrations and chronic kidney disease status, baseline intact parathyroid or fibroblast factor 23 concentrations.

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