Li Y, Liu Q, Kang C, et al. - Researchers sought to determine the expression features of ANGPTL8 (a newly recognized angiopoietin-like protein family member) in patients suffering from primary nephrotic syndrome (PNS) as well as its likely correlation with hyperlipidemia and proteinuria. Participants were 133 patients with PNS and 60 healthy controls, in whom, ANGPTL8 levels were ascertained via an enzyme-linked immunosorbent assay. Higher levels of serum and urine ANGPTL8 were detected in patients with primary nephrotic syndrome vs healthy controls. A positive correlation of serum ANGPTL8 with cholesterol as well as with triglycerides was identified in primary nephrotic syndrome cases, while there was no correlation with 24 h urine total protein. Overall, it was found in primary nephrotic syndrome patients that a correlation existed of serum and urine ANGPTL8 levels with blood lipid levels and proteinuria, respectively, indicating a likely role of ANGPTL8 in the occurrence of primary nephrotic syndrome hyperlipidemia and proteinuria.