Aregbesola A, et al. - The relationships of baseline and average of 4-year change in values of serum adiponectin (sA), serum ferritin (sF) and sA/sF ratio on type 2 diabetes (T2D) risk and insulin sensitivity (Matsuda ISI) and secretion (disposition index; DI₃₀) were investigated in this study. They conducted prospective analyses in members with impaired glucose tolerance of the Finnish Diabetes Prevention Study recruited in 1993-1998. They used Cox and linear regression analyses to examine the associations of sA, sF and sA/sF ratio, as continuous variables, with incident T2D, Matsuda ISI, and DI₃₀. The results of this study revealed that baseline levels and changes during the follow-up in sA and sA/sF ratio were associated with T2D risk and insulin sensitivity.