Makaronidis J, Mok J, Balogun N, et al. - Researchers investigated the seroprevalence of SARS-CoV-2 antibodies in a community-based population with acute loss of smell and/or taste. In addition, they compared the frequency of COVID-19 linked symptoms in participants with and without SARS-CoV-2 antibodies and evaluated predictive value of smell or taste loss for COVID-19 infection. People registered with a number of primary care centers in London were sent text messages inviting those having a new loss in their sense of smell and/or taste to participate in this study. Online questionnaires concerning demographics, their loss of smell and/or taste, and other COVID-19 symptoms were filled by the recruited participants, before they had a telemedicine consultation with a healthcare professional who confirmed the history of their symptoms and supervised a test to find out if they had SARS-CoV-2 antibodies. SARS-CoV-2 antibodies were identified in a total of 78% of 567 people with smell and/or taste loss; neither cough nor fever was reported in 40% of these, and participants with loss of smell were noted to be 3 times more likely to have SARS-CoV-2 antibodies, compared with those with loss of taste. Findings are thereby suggestive of high specificity of recent loss of smell as a COVID-19 symptom and emphasize considering it more generally in guiding case isolation, testing, and treatment of COVID-19.