Pane S, et al. - Researchers aimed to compare the performance of two commercially available tests for serological diagnosis of Chagas disease (CD) in a group of Latin American migrants living in a non-endemic setting (Rome, Italy). They also searched for epidemiological risk factors associated with CD in this study population. The lack of a reference standard serological assay for diagnosis makes the serological diagnosis of CD challenging. As per results, performing CD screening in non-endemic countries is significant. For mass screening of low-risk patients, employing a fully automated and highly sensitive CMIA assay first could be a cost- and resource-effective strategy. However, for patients coming from endemic countries, the WHO strategy of using two different serological assays, combined with epidemiological information, was supported to be the best approach.