Tang X, et al. - Researchers attempted to study the accuracy of two semi-automatic segmentation measurements based on magnetic resonance imaging (MRI) three-dimensional (3D) Cube fast spin echo (FSE)-flex sequence in phantoms, as well as to assess the feasibility of determining the volumetric alterations of orbital fat (OF) and total extraocular muscles (TEM) in patients with thyroid-associated ophthalmopathy (TAO) by semi-automatic segmentation. By using Cube FSE-flex sequence with a 3 T MRI system, 44 fatty (n=22) and lean (n=22) phantoms were scanned. According to the findings obtained, MRI Cube FSE-flex determined multi-dimensional threshold (MDT) was a relatively accurate semi-automatic segmentation that could be used to assess orbital fat and TEM volumes in the clinic.