Boeri L, Pederzoli F, Capogrosso P, et al. - Researchers conducted a cross-sectional study examining if and how asymptomatic semen infections affect seminal parameters in men presenting for primary couple’s infertility. In 1,689 men, semen analysis was performed based on 2010 World Health Organization reference criteria. Per outcomes, asymptomatic semen infections were evident in one out of five men presenting for a couple’s primary infertility, which were significantly linked with impaired sperm concentration. The most frequent single pathogen was Ureaplasma urealyticum (37.6%), followed by Enterobacteriaceae (any type; 24.8%), other pathogens (20.3%), Chlamydia trachomatis (3.4%) and Mycoplasma spp (3.4%). Lower sperm concentrations and progressive motility were observed in correlation with positive semen cultures; these were most particularly observed in men with infections caused by Ureaplasma urealyticum compared with negative semen cultures. These observations emphasize the significance of a precise investigation of semen infection in the everyday clinical practice diagnostic workup of infertile men.