Aksoy GK, et al. - In this retrospective study involving male adolescents of age more than 14 years, researchers searched the frequency of sperm abnormalities of adolescent boys with familial Mediterranean fever (FMF) and also examined if disease activity or colchicine treatment have negative impacts on sperm parameters. Multivariate regression analysis found the presence of FMF attacks under treatment to be a risk factor for decreased motility in the study group. In patients with low sperm counts, the erythrocyte sedimentation rate at the time of diagnosis was high vs those with normal sperm counts. In patients with low sperm motility, the mean dose of colchicine at the time of sperm analysis was higher than that of normal sperm motility. Overall, the investigators concluded that sperm abnormalities in male FMF patients are not infrequent, and due to uncontrolled disease and colchicine therapy it is linked to both inflammations.