Greaney JL, et al. – In this study, researchers investigated whether more severe impairments in endothelium-dependent dilation (EDD) could be detected in young adults with major depressive disorder (MDD) exposed to everyday psychosocial stressors vs healthy nondepressed adults (HCs). They also studied adults with MDD without acute psychosocial stress exposure. Participants included 20 HCs and 23 otherwise healthy adults with MDD who were asked to complete a psychosocial experiences survey to report exposure to any of 6 stressors over the preceding 24 hours (eg, arguments, work stressors). During graded intradermal microdialysis perfusion of acetylcholine (10⁻¹⁰ to 10⁻¹mol/L), they recorded red cell flux (laser Doppler flowmetry). EDD was expressed as a percentage of maximum vascular conductance (flux/mm Hg). Greater impairments in endothelial function were observed in relation to exposure to everyday psychosocial stressors in patients with MDD, which was indicative of a potential mechanistic link between daily stress and depression in increased cardiovascular risk.