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Selective laser trabeculoplasty vs eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): A multicentre randomized controlled trial

The Lancet Mar 14, 2019

Gazzard G, et al. - Researchers undertook this observer-masked, randomized controlled trial performed recruiting treatment-naive patients with open angle glaucoma or ocular hypertension and no ocular comorbidities between 2012 and 2014 at six UK hospitals to compare treatment outcomes using eye drops, that lower intraocular pressure, vs initial selective laser trabeculoplasty in these patients. They enrolled 718 patients in this study, of these, 356 underwent selective laser trabeculoplasty and 362 received eye drops. As per outcomes, they recommend offering selective laser trabeculoplasty as a first-line treatment for open-angle glaucoma and ocular hypertension. In terms of cost-effectiveness, initial selective laser trabeculoplasty was more cost-efficacious compared to the conventional treatment pathway, where medication is used from the outset, with no significant difference in health-related quality of life and clinical outcomes.
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