Irelli EC, Morano A, Orlando B, et al. - A cohort of juvenile myoclonic epilepsy (JME) patients was examined over a long-term follow-up in order to report in the temporal course of medication response and linked prognostic factors in this cohort.

• Retrospective review of data from 113 JME patients diagnosed according to recently proposed class II criteria.

• Seventy-six of 113 (67.3%) individuals obtained 4-year seizure remission; 45/76 (59.2%) patients showed achievement of early sustained remission.

• Multivariable multinomial logistic regression analysis revealed significant correlation of absence seizures with no-remission.

• Delayed sustained remission was observed in significant correlation with presence of catamenial seizures and earlier age at epilepsy onset.

• 15.7% of patients with early sustained remission and 35.5% of those with delayed sustained remission showed spontaneous seizure relapse after 4-year remission.

• Irregular lifestyle habits and pregnancy-related switch from valproate to another ASM were identified to be the most common concomitant factors for a spontaneous relapse.

• At univariable analysis, more frequent occurrence of a spontaneous generalized tonic-clonic seizure relapse was recorded after 4-year remission among patients with a history of catamenial seizures.