Bellettiere J, et al. – In this study, researchers investigated whether patterns of sedentary time are linked to a higher risk of cardiovascular disease (CVD) among 5,683 women (aged 63-97 years) from the Objective Physical Activity and Cardiovascular Health (OPACH) Trial. Study participants were followed up for up to 4.9 years for CVD events, had no history of myocardial infarction or stroke, and wore accelerometers for 4-7 days for activity monitoring. They estimated hazard ratios (HRs) and 95% CIs for CVD by using Cox regression models adjusted for covariates and for potential mediators. A total of 545 CVD events were recorded over 19,350 person-years. After adjusting for covariates, women with the highest vs the lowest quartile of sedentary time were found to have a greater risk for CVD. In addition, women who had both high sedentary time and long mean bout durations had significantly higher CVD risk vs women with low sedentary time and shorter mean bout durations.