Zloto O, Minard‐Colin V, Boutroux H, et al. - In this bicentric retrospective study, researchers investigated the features of patients with recurrent/refractory‐orbital rhabdomyosarcoma (oRMS), concentrating on local therapy. The sample consisted of young patients (< 30 years) with R/R‐oRMS who were treated at the Institut Curie and Gustave Roussy Cancer Campus, France, from 1989 to 2018. Results revealed that 27 out of 162 patients (17%) with oRMS presented with R/R disease. Findings suggested that R/R‐oRMS is a rare situation. Second-line therapy at this location is effective, often at the expense of lifesaving mutilating surgery. Therefore, second‐line local therapy needs to consider local radiotherapy if possible or complete wide surgery.