Ndiaye JLA, et al. - In the Saraya district in south-east Senegal in 2011, investigators estimated the efficacy of seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine plus amodiaquine administered over 5 months to kids under 10 years old. Community health workers (CHWs) confirmed malaria cases by a rapid diagnostic test (RDT). They reported that 111 fewer malaria cases per 1,000 children per month in kids under 5 years of age and 101 fewer cases per 1,000 children per month in children aged 5-9 years was related to SMC vs community case management alone. They found a correlation of SMC with an 18% decrease in the percentage of children with anemia at the end of the transmission season. Compared to community case management alone, they noted a 73% decline in the percentage of children with malaria parasitemia. They overall found no reduction in mortality; the effect of SMC on severe malaria was not assessed.