Retnakaran R, et al. - Researchers examined how the antepartum glucose challenge test (GCT) is associated with subsequent postpartum cardiovascular risk factor profile. For this work, a screening GCT was performed in 503 women in late second trimester and then cardiometabolic characterization was performed at 3 months postpartum, whereupon they compared traditional (blood pressure, glucose, lipids) and nontraditional (apolipoprotein B, C-reactive protein, adiponectin) cardiovascular risk factors across GCT tertiles. As per multiple linear regression analyses, the GCT was identified to be a significant independent predictor of higher fasting glucose, 2-hour glucose, total cholesterol: high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein cholesterol, and apolipoprotein B and of lower high-density lipoprotein cholesterol and adiponectin. Moreover, after excluding women who had gestational diabetes mellitus, these independent associations persisted. These findings support the possible value of antepartum GCT for the identification of women with an adverse underlying cardiovascular risk factor phenotype.