Chatzopoulos GS, et al. - Twenty-five chronic periodontitis cases and 25 periodontally healthy controls were examined to study the levels of sclerostin (SOST), WNT-5a, and TNF-α in chronic periodontitis vs periodontally healthy sites and also to estimate their value as diagnostic markers of chronic periodontitis. When compared to the generalized healthy, significantly higher protein levels of SOST were observed in the generalized moderate and severe chronic periodontitis subgroup. They noted significantly higher total protein levels of WNT-5a on diseased sites in the periodontitis cases than in healthy sites, whereas no differences were reported for SOST and TNF-α. Similar total protein levels of SOST, WNT-5a, and TNF-α in GCF were detected in periodontitis and subjects with non-periodontitis. They suggested a low accuracy for localized chronic periodontitis but a high diagnostic value for generalized moderate and severe chronic periodontitis with sclerostin and WNT-5a gingival protein levels.